AIM: To observe the image features of Vogt-Koyanagi-Harada disease(VKH)and multiple central serous chorioretinopathy(CSC)by fundus fluorescein angiography(FFA)and optical coherence tomography(OCT).

METHODS: Thirty-two eyes of 17 patients with VKH and thirty-five eyes of 30 patients with multiple CSC were collected from 2009 to 2016 in my hospital.

RESULTS: All the eyes with VKH were found small and dense fluorescein leakage in the early stage. The 17 eyes(53%)with VKH were found fluorescein accumulation in the final stage; 24 eyes(75%)with VKH were found high fluorescence of optic disc. All of eyes with multiple CSC were found multifocal leakage in the early stage. And 2 eyes(6%)with multiple CSC were found high fluorescence of optic disc. There were 28 eyes(14 patients)with VKH and 25 eyes(22 patients)with multiple CSC had been done OCT in my hospital. Retinal pigment epithelial fold was only found in VKH. Fluctuation of internal limiting membrane(ILM)and membrane structure had higher sensitivity to diagnostic VKH from to multiple CSC, with sensitivity of 54% and 68% respectively.

CONCLUSION: There are some similarities as well as differences between FFA and OCT in diagnosis of VKH and multiple CSC. A combination usage of FFA and OCT can be more effective in distinguishing VKH from multiple CSC.