AIM: To investigate the effect of intravitreal injection of anti-vascular endothelial growth factor(VEGF)drugs combined with other methods in the treatment of Coats disease.

METHODS: Selected 13 patients 13 eyes with Coats disease in our hospital from May 2013 to May 2016. All eyes were treated with intravitreal injection of ranibizumab and combined with scleral drainage, laser photocoagulation and so on. We observed visual acuity and retinal reattachment.

RESULTS: In 13 eyes, the treatment of 4 eyes with intravitreal injection of ranibizumab and combined with scleral drainage, 3 eyes combined laser photocoagulation, 6 eyes combined vitrectomy, membrane peeling, freezing, silicone oil filling or other treatments. Eyeball retention rate was 100%. Visual acuity at 6mo after treatment significantly improved compared with before treatment(P<0.05). The visual acuity was ≥0.05-0.1, 0.01-<0.05, counting finger, light perception and hand moving before treatment in 0, 0, 38%, 38% and 23%, after treatment were 23%, 23%, 38%, 15% and 0. Complete retinal reattachment was achieved in 5 eyes, accounting for 38%; basic reset in 3 eyes, accounting for 23%; 5 eyes were not reset, accounting for 38%.

CONCLUSION: Intravitreal injection of anti-VEGF drugs combined with other methods for the treatment of Coats disease have a certain effect, can improve or maintain the limited visual function, avoid enucleation of eyeball due to disease progression.