目的：比较分析重组牛碱性成纤维细胞生长因子(bFGF)滴眼液与羟糖甘滴眼液对年龄相关性白内障患者术后泪膜稳定性及干眼症状的影响。

方法：随机数字法将115例115眼年龄相关性白内障术后干眼患者分为bFGF组、羟糖甘组及空白对照组，空白对照组仅给予常规抗炎治疗，bFGF组、羟糖甘组在空白对照组基础上分别加以bFGF滴眼液、羟糖甘滴眼液治疗，比较各组临床疗效、不良反应、不同时间点干眼症状评分、基础泪液分泌试验(SⅠt)、泪膜破裂时间(BUT)、角膜荧光素染色(CFS)评分变化情况。

结果：bFGF组治疗总显效率89.5%比羟糖甘组的70.3%、空白对照组的47.5%高，差异有统计学意义(P<0.05)； 三组患者术后2、5wk干眼症状评分、CFS评分、SⅠt、BUT比较差异有统计学意义(P<0.05)，且bFGF组术后2、5wk上述指标均显著优于羟糖甘组及空白对照组，羟糖甘组上述指标均显著优于空白对照组，差异具有统计学意义(P<0.05)； 三组患者均无明显不良反应发生。

结论：年龄相关性白内障术后早期泪膜不稳定，出现干眼症状，bFGF滴眼液、羟糖甘滴眼液干预均能有效恢复患者泪膜稳定性，显著改善干眼症状，其中bFGF滴眼液效果更显著。

METHODS: A total of 115 patients(115 affected eyes)with dry eyes after age-related cataract surgery were divided into the bFGF group, the hydroxyl indican group and the blank control group by the random number table method. The blank control group was only given routine anti-inflammatory treatment, and on the basis, the bFGF group and the hydroxyl indican group were treated with bFGF eye drops and hydroxyl indican eye drops respectively. The clinical efficacy, adverse reactions, changes in scores of dry eye symptoms, Schirmer test(SⅠt), tear film break-up time(BUT)and corneal fluorescein staining(CFS)scores at different time points were compared among the three groups.

RESULTS: The total markedly effective rates in the bFGF group(89.5%)was higher than that in the hydroxyl indican group(70.3%)or the blank control group(47.5%)(P<0.05). Scores of dry eye symptoms, CFS, SⅠt and BUT in the three groups at 2 and 5wk after surgery were significantly different(P<0.05). The above-mentioned indexes in the bFGF group at 2 and 5wk after surgery were significantly better than those in the hydroxyl indican group and the blank control group, and better in the hydroxyl indican group than the blank control group(P<0.05). There were no obvious adverse reactions.

CONCLUSION: The tear film is unstable in early stage after age-related cataract surgery, and there are dry eye symptoms. The intervention with bFGF eye drops and hydroxyl indican eye drops can effectively restore the tear film stability and significantly relieve dry eye symptoms, and the effect of bFGF eye drops is more significant.