方法：采用前瞻性病例对照研究，分别记录2014-11/2016-08来院就诊的AMD患者和性别匹配的对照组患者简易精神状态检查表(minimum mental state examination，MMSE)和老年抑郁量表(the geriatric depression scale，GDS)得分，并行统计学分析。

结果：AMD组和对照组患者共84例168眼纳入研究。基线资料比较，最佳矫正视力(best corrected visual acuity，BCVA)差异有统计学意义(F=8.953，P=0.004)。相同受教育情况两组MMSE得分差异均无统计学意义(P>0.05)； 总体认知障碍患病率比较，差异有统计学意义(χ²=4.14，P=0.042)。两组患者GDS得分差异有统计学意义(F=5.852，P=0.018)； 抑郁总患病率及轻度抑郁患病率差异有统计学意义(χ²=6.372，P=0.012； χ²=5.674，P=0.017)； 中重度抑郁患病率差异无统计学意义(χ²=0.672，P=0.412)。

结论：AMD患者具有更高的抑郁症患病率，虽然基于受教育程度的分组MMSE得分差异不具有统计学意义，但总体较对照组更易患认知障碍。

METHODS: A prospective case-control study was performed from November 2014 to August 2016 in the hospital for AMD patients and sex-matched control group. The Mini-Mental State Examination(MMSE)and the Geriatric Depression Scale(GDS)score of each patient were collected for statistical analyzing.

RESULTS: There were total 84 cases(168 eyes)included in the study. The difference of visual acuity between the two group was statistically significant(F=8.953, P=0.004)by baseline data analyzing. There were no significant differences in MMSE scores between the two groups according to educational status(P>0.05), while the prevalence of cognitive impairment in each group was statistically significant(χ²=4.14, P=0.042). The difference of GDS scores, prevalence of total and mild depression between two groups were both statistically significant(F=5.852, P=0.018; χ²=6.372, P=0.012; χ²=5.674, P=0.017). However, there was no statistically significant difference in the prevalence of moderate to severe depression(χ²=0.672, P=0.412).

CONCLUSION: AMD patients have a higher prevalence of depression. Although MMSE score differences were not statistically significant in subgroup analysis by educational levels, AMD patients are more likely to have cognitive impairment overall.