AIM:To analyze the clinical efficacy of conjunctival flap covering combined with subconjunctival injection of fluconazole on patients with severe fungal corneal ulcer.

METHODS: Totally 50 cases with severe fungal corneal ulcer were collected in our hospital from January 2012 to December 2015. The cases were randomly divided into observation group and control group, 25 cases in each group. All the cases were monocular sick. The control group took single drug treatment, but the observation group were given with conjunctival flap as an extra. The clinical efficacy, best corrected visual acuity and adverse effects rate were observed. And, the relapse of the two groups was followed for 1a.

RESULTS: After 1mo of treatment, the clinical curative effect of the observation group was significantly higher than the control group(P<0.05), and corrected visual acuity of the observation group was higher than the control group(P<0.05); the adverse reaction rate of the observation group was lower than the control group(P<0.05).After 1a follow-up, the observation group only had 1 case of recurrence, control group had 8 cases with recurrence, the recurrence rate of the observation group was significantly lower than the control group(P<0.05).

CONCLUSION:The conjunctival flap combined with subconjunctival injection of fluconazole has good application value in severe fungal corneal ulcer patients, can effectively improve the clinical curative effect and the visual acuity, and can effectively reduce the incidence of adverse reactions and recurrence rate.