AIM: To study the effects of timolol and latanoprost on optic disc parameters and retinal nerve fiber layer thickness of high intraocular pressure type POAG patients, and to provide guidance for clinical research.

METHODS: Totally 240 patients(336 eyes)with high intraocular pressure type POAG in our hospital from November 2013 to November 2015 were randomly divided into control group and observation group, and each with a total of 120 cases(170 and 166 eyes, respectively). The patients in control group only received latanoprost treatment, while the observation group was treated with timolol and latanoprost treatment. After 3mo of treatment, we observed the therapeutic effects, and measured the optic disc parameters and retinal nerve fiber layer thickness. The incidence of adverse reactions was observed in the following 1a.

RESULTS: The patients of observation group and the control group after treatment showed the improvement rates of 97.6% and 80.6%, respectively, and the observation group was significantly better than the control group, the two groups showed statistically significant(P<0.05). The eye rim area, rim volume, rim volume and diameter of two groups after treatment were higher than before(P<0.05), while those of the observation group was significantly higher than control group(P<0.05). Two groups of patients with vertical cup to disc diameter decreased obviously(P<0.05), the observation group was significantly lower than the control group, the difference was statistically significant(P<0.05). Between the two groups of patients, during the period, incidences of dry eyes, corneal and conjunctival hyperemia, infiltration blurred vision and other complications had no significant difference(P>0.05), and the 1a follow-up of patients showed no other adverse reactions.

CONCLUSION: The use of timolol and latanoprost therapy for high intraocular pressure type POAG patients showed that the patients improve obviously, the visual acuity has more improved and the parameters of optic disc and retinal nerve fiber layer thickness are also improved.