AIM: To investigate the efficacy and safety of minimally invasive vitrectomy with 23G and 25G+ in the treatment of rhegmatogenous retinal detachment.

METHODS: From August 2015 to August 2016, 130 cases of rhegmatogenous retinal detachment patients were chosen as the research object. According to the random number table method, 130 patients were divided into experimental group and control group, 65 cases in each group. The experimental group received 25G+ minimally invasive vitrectomy, the control group was given 23G minimally invasive vitrectomy. The operation time, complication rate, retinal reattachment, visual acuity, intraocular pressure and postoperative complications were compared between the two groups.

RESULTS: The operative time was 69±11min in control group and 66±12min in the experimental group(P>0.05). The experimental group had 3 cases of iatrogenic retinal breaks, intraoperative complication rate was 4.6%, the control group of 5 cases of iatrogenic retinal breaks during the operation, the complication rate was 7.7%(P>0.05). The experimental group disposable retinal reattachment rate was 96.9%, the final reduction rate was 90.8%; the control group disposable retinal reattachment rate was 93.9%, the final reduction rate was 87.7%, those differences between the experimental group and the control group were no significant(P>0.05). At the end of the follow-up visual acuity of experimental group was logMAR 0.241±0.062, control group 0.253±0.057, significantly different compared with before treatment(P<0.05), while not different between the two groups(P>0.05). intraocular pressure of the two groups were not significantly different before and after surgery(P>0.05). The complication rate was 44.6% after operation in the experimental group, the complication rate was 63.1% in control group(P<0.05).

CONCLUSION: The 25G+ minimally invasive vitrectomy in the treatment of rhegmatogenous retinal detachment is safe and effective, less operative trauma, rapid postoperative recovery, less postoperative complications compared with 23G vitrectomy.