AIM: To analyze the changes of retinal hemodynamics in patients with diabetic retinopathy(DR)by color Doppler ultrasonography.

METHODS: Totally 96 patients(96 eyes)with diabetes mellitus(DM)treated in our hospital from June 2014 to May 2017 were selected and divided into A, B, C three groups. Group A consisted of 32 DM patients(32 eyes), Group B with 32 cases(32 eyes)of non-proliferative diabetic retinopathy(NPDR), Group C 32 cases(32 eyes)of proliferative diabetic retinopathy(PDR), and 30 healthy volunteers(30 eyes)were set as control group. All patients' the central retinal artery(CRA), posterior ciliary artery(PCA), ophthalmic artery(OA)hemodynamic changes were detected by color Doppler ultrasound. And the relation of HbA1c and FBG with diabetic lesion degree were studied.

RESULTS: The hemodynamic indexes of CRA, PCA and OA in each group were statistically significant(P<0.05). The difference of PSV of CRA, PCA and OA in Group A and control group was not statistically significant(P>0.05). The PSV and EDV of CRA, PCA and OA in Group C were the lowest, and the RI was the highest, which had a significant difference between Group A and B(P<0.05). HbA1c and FBG in each group showed statistical significance(P<0.05). Course of disease in Group A and Group C only showed significantly different(P<0.05).

CONCLUSION: Color Doppler ultrasound monitoring changes of CRA, PCA, OA hemodynamics in diabetic patients can bring us more understand in retinal blood flow, and play a vital role in prevention and treatment of diabetic retinopathy.