AIM:To investigate the effect of scleral slap invagination and trabeculectomy combined with amniotic membrane implantation in the treatment of glaucoma.

METHODS: From May 2013 to June 2017, 98 cases(116 eyes)with glaucoma were treated in our hospital. According to the random number table method, the patients were divided into two groups: the observation group of 45 cases(58 eyes)with scleral slap invagination surgery combined with amniotic membrane transplantation into operation, the control group of 53 cases(58 eyes)with trabeculectomy combined with amniotic membrane implantation. Postoperatively patients were followed up for 3mo to observe IOP control; using MEN-C90 type blood rheology analyzer to detect the whole blood viscosity, plasma viscosity, hematocrit and blood viscosity changes, using the Doppler flow imaging(CDFI)technique for the detection of ophthalmic artery end diastolic velocity(EDV), RI, and the peak systolic velocity(PSV)and other hemodynamic parameters change.

RESULTS: One week and 3mo after the surgery, mean IOP of the observation group was 12.18±0.98mmHg,12.23±0.94mmHg, the control group was 14.49±1.64mmHg, 14.62±1.59mmHg, the difference was statistically significant(P<0.05); IOP successful-control rate of observation group after operation was 81.0%, more than that of the control group(61.3%), the difference was statistically significant(P<0.05). At 1wk and 3mo after operation high blood viscosity, plasma viscosity, hematocrit and blood viscosity of two groups decreased significantly compared with the preoperative(P<0.05); those of the observation group were better than those of the control group(P<0.05). At 1wk and 3mo after operation, EDV and PSV of the two groups increased significantly, RI decreased significantly, compared with the preoperative differences were statistically significant(P<0.05), those of the observation group were better than those of the control group(P<0.05).

CONCLUSION: The combination of scleral slap invagination and amniotic membrane implantation has a significant effect on glaucoma patients, the effect of intraocular pressure control is good, the postoperative complications are low, and the safety of the patients is high.