AIM: To investigate the effect of phacoemulsification intraocular lens implantation combined with trabeculectomy on ocular surface in the treatment of glaucoma and cataract.

METHODS: Totally 45 cases of patients with glaucoma and cataract in our hospital from February 2016 to February 2017 were enrolled. All the patients had unilateral disease, and the medical records of the patients were analyzed retrospectively. The sicked eyes were set as the observation group and contralateral eyes were set as the control group. The dry eye score, break-up time(BUT), corneal fluorescein staining score(FL), tear secretion test(SⅠt)and conjunctival epithelium goblet cell density(CIC)was compared between two groups before operation and at 1wk, 1 and 3mo after operation.

RESULTS: The preoperative dry eye score of the observation group had no significant difference with that of the control group(P>0.05). At 1wk, 1mo after operation, data of the observation group was significantly higher than that of the control group and before operation, with statistical significance(P<0.05), no significant difference was shown at postoperative 3mo(P>0.05). Preoperative BUT of the observation group had no significant difference with that of the control group(P>0.05); at 1 wk,1 and 3mo after operation, data of the observation group was significantly lower than that of the control group and before operation, with statistical significance(P<0.05). The preoperative FL score of the observation group was significantly higher than that of the control group, while the postoperative FL score of the observation group at 1wk, 1 and 3mo had sharp difference with that before operation(P<0.05), all were significantly higher than that of the control group, there was statistical significance(P<0.05). There was no significant difference in SⅠt score between the observation group and the control group preoperatively(P>0.05), and the postoperative SⅠt scores of the observation group at 1wk, 1 and 3mo postoperatively was evidently lower than that of the control group and before operation(P<0.05). There was no significant difference in CIC density between the two groups preoperatively. While the postoperative data of the observation group at 1wk, 1 and 3mo postoperatively was significantly lower than that of the control group and before operation, with statistical points(P<0.05).

CONCLUSION: Phacoemulsification intraocular lens implantation combined with trabeculectomy for treatment of glaucoma and cataract can aggravate dry eye symptoms, as well as reduce tear film stability and tear secretion, impair conjunctival epithelium goblet cell.