AIM: To study the effect of calcium dobesilate combined with panretinal photocoagulation on severe non-proliferative diabetic retinopathy patients(NPDR).

METHODS:A total of 92 patients(184 eyes)with severe NPDR were collected in our hospital from December 2014 to April 2017, and divided into laser group and combined treatment group by random number table method. The laser group was treated with panretinal laser photocoagulation, and the combined treatment group received calcium dobesilate combined with retinal laser photocoagulation. The effect of the two groups was compared on the retinal microcirculation parameters.

RESULTS: Seven weeks after treatment, treatment effective rate in combined treatment group was higher than that in laser group(P<0.01). Fundus examination parameter such as Ops OS2, subfoveal choroid thickness(SFCT)in combined treatment group were higher than those in laser group(P<0.01). Retinal microcirculation parameters such as PSV, MV in combined treatment group were higher than the level of the laser group, RI, PI levels were lower than those in laser group(P<0.01).

CONCLUSION: Calcium dobesilate combines with panretinal photocoagulation in severe NPDR patients can effectively improve the overall effect and optimize the fundus structure and retinal microcirculation.