AIM: To explore clinical effect of pranoprofen combined with deproteinized calf blood extract eye drops for moderate to severe dry eye.

METHODS: A total of 84 patients(132 eyes)who received treatment at the Zhengzhou Second Hospital were selected from January 2016 to January 2017. According to random number table method they were divided into control group 42 cases(68 eyes)and observation group 42 cases(64 eyes), the control group using polyvinyl alcohol eye drops with pranoprofen, observation group with pranoprofen with deproteinized extract of calf blood eye drops. Subjective and objective scores before and after treatment were recorded.

RESULTS: There was no statistically significant difference on the four objective indicators of pretreatment FL, BUT, SⅠt, and vision between the two groups(P>0.05). Dry eye symptom scores of the two groups decreased after treatment, both with significantly different(P<0.05); after treatment, the symptom scores of the observation group were significantly lower than those in the control group, and the difference was statistically significant(P<0.05), indicating that the subjective symptoms of the observation group were better than that of the control group after treatment. After treatment of the control group and the observation group, the FL index was significantly lower than before treatment, BUT, SⅠt and vision were significantly higher than before treatment, and the differences within either group were statistically significant(P<0.05); those indexes of observation group were different compared with control group(P<0.05), indicating that the objective symptoms of the observation group were better than that of the control group after treatment. None of the patients showed serious adverse reactions.

CONCLUSION: The clinical effect of praprofen on the treatment of moderate to severe dry eye with the deproteinized calf blood extract is better.