AIM: To investigate the clinical characteristics of secondary glaucoma caused by lens suspensory ligament laxity or occult subluxation, and to analyze the influence of operation on visual acuity and intraocular pressure(IOP).

METHODS: Totally 38 cases(38 eyes)of the secondary glaucoma caused by lens suspensory ligament laxity or occult subluxation in ophthalmology department of our hospital from December 2014 to December 2016 were enrolled and their medical records were analyzed retrospectively to observe the clinical characteristics of glaucoma. Preoperative mydriasis was carried out and surgical methods were chosen according to the lenses location and extent of suspensory ligament. Preoperative and postoperative anterior chamber depth, corneal endothelial cell density, IOP, visual field, visual acuity and complications were analyzed.

RESULTS: The average intraocular pressure was 18.17±1.43mmHg at postoperatively 10d, which was significantly lower than 38.77±2.45mmHg before operation, the difference had statistical significance(P<0.05). The IOP of 25 eyes returned to normal(≤21mmHg)at 3d after surgery. The IOP of 34 eyes with the usage of IOP lowering medication returned to normal at postoperative 10d. The IOP of 4 eyes came to normal after undergoing glaucoma drainage valve implantation again. There were 5 eyes with visual acuity ranged 0.1 to <0.2, 17 eyes 0.2 to <0.5, 16 eyes ≥0.5 preoperatively, and 2 eyes, 17 eyes and 19 eyes postoperatively, the difference was not significant(P>0.05). The postoperative anterior chamber depth was 2.45±0.44mm, which was significantly higher than 1.23±0.35mm before operation, the difference had statistical significance(P<0.05). The postoperative corneal endothelial cell density was 878.34±322.12/mm² and decreased significantly, compared with 1735.32±340.32/mm² before operation, the difference had statistical significance(P<0.05). There were 8 eyes with corneal edema, 4 eyes with iris adhesion or varying degrees of atrophy, 3 eyes with anterior chamber hemorrhage, and 2 eyes with pupil exudate at 3d after surgery.

CONCLUSION: Clinical symptoms and signs of secondary glaucoma in patients with lens suspensory ligament laxity or occult subluxation are more complex, which needs to be distinguished with other types of glaucoma in clinical treatment, and its surgical methods shall be chosen according to different suspensory ligament site and lens subluxation scope.