AIM: To investigate the clinical efficacy of intravitreal injection of Conbercept combined with trabeculectomy and panretinal photocoagulation for the treatment of neovascular glaucoma(NVG).

METHODS: The clinical data of 90 patients with NVG treated in our hospital from June 2014 to June 2016 were analyzed retrospectively. There were 42 patients treated with trabeculectomy and panretinal photocoagulation enrolled as the control group. On the basis of this, 48 patients who received intravitreal injection of conbercept 5-7d preoperatively were enrolled as observation group. The best corrected visual acuity(standard logarithmic visual acuity), intraocular pressure and the regression of neovascularization were observed and compared before treatment, and 1wk, 1, 3, and 6mo post treatment. Then the clinical efficacy and postoperative complications were observed and recorded.

RESULTS: The difference of visual acuity of the two groups was significant before and after treatment, and the best corrected visual acuity of observation group was significantly higher than that of the control group at 1mo after the operation(P<0.05), no difference was found at 1wk, 3 and 6mo post treatment(P>0.05). The pre- and postoperative intraocular pressure of the two groups showed significant difference, and the intraocular pressure of the observation group was significantly lower than the control group at 1wk, 1, 3 and 6mo post treatment(P<0.05). The cure rate in the observation group was significantly higher than that in the control group(77% vs 64%), with statistical significance(P<0.05). The incidence of anterior chamber hemorrhage and shallow anterior chamber in the observation group was significantly lower than that of the control group(P<0.05), with no difference in the incidence of macular degeneration(P>0.05). Moreover, the recurrence rate of neovascularization in the observation group was significantly lower than that of the control group at 6mo after operation(P<0.05).

CONCLUSION: The intravitreal injection of conbercept 5-7d before panretinal photocoagulation can significantly reduce intraocular pressure, improve the visual acuity for the treatment of NVG, which also has a higher comprehensive cure rate.