AIM:To comparatively analyze the effect of wavefront aberration or corneal topography guided laser-assisted in situ keratomileusis(LASIK)on the visual quality in patients with myopia after surgery.

METHODS: During the period of January 2016 to January 2017, 100 patients(a total of 200 affected eyes)with myopia in our hospital were selected as the subjects, and they were randomly divided into Group A and Group B with 50 cases in each group. Before surgery, the eyes were examined and LASIK was performed. During surgery, the corneal stroma of eyes in Group A was cut individually according to the results of wavefront aberration examination while the individual cutting in Group B was performed according to the data of corneal topography. The visual acuity and visual quality were compared between the two groups after surgery.

RESULTS: There was no significant difference of the visual acuity between the two groups before surgery(P>0.05). The Log MAR uncorrected visual acuity(UCVA), Log MAR BCVA and diopter were significantly improved at 6mo after surgery(P<0.05), and the diopter of Group A at 6mo after surgery was lower than that of Group B(P<0.05). There was no significant difference of contrast sensitivity(CS)between the two groups before surgery(P>0.05). But CS of different optotypes in two groups at 3mo after surgery were all better than those before surgery(P<0.05). There was no significant difference between the two groups in CS under the bright and non-glare condition at 3mo after surgery(P>0.05). However, CS of Group A under bright glare, dark with glare and dark without glare states were significantly better than those of Group B(P<0.05). There was no significant difference of detection results of wavefront aberrations between the two groups before surgery(P>0.05). At 3mo after surgery, the total aberrations, total higher-order aberrations, comatic aberrations and spherical aberrations significantly increased in two groups(P<0.05), and the increase in Group A was obviously lower than that in Group B(P<0.05).

CONCLUSION: Both of wavefront aberration and corneal topography guided individualized excimer surgery can significantly improve the visual acuity of patients with myopia, but the former has more advantages in improving the visual quality.