AIM: To analyze the effect of intravitreal injection of Conbercept before pars plana vitrectomy(PPV)on complications and visual recovery in patients with proliferative diabetic retinopathy(PDR).

METHODS: Totally 94 patients with PDR(monocular onset)were randomly divided into the experimental group(n=47)and the control group(n=47). All patients were treated by PPV. The experimental group was treated with intravitreal injection of conbercept at 5-7d before PPV while the control group was not given the intervention. The surgical time, surgical procedures, complications and visual recovery in the two groups were observed and statistically analyzed.

RESULTS: The operating time of PPV for the experimental group was significantly shorter than that for the control group(72.33±15.71min vs 91.06±19.29min, P<0.05). The incidence rates of intraoperative electric coagulation hemostasis, iatrogenic breaks and hemorrhage of new vessels in the experimental group(4%, 2% and 6%)were significantly lower than those in the control group(19%, 15% and 26%; P<0.05). The mean Log Mar acuity BCVA and the macular thickness decreased significantly of the two groups at 3mo and 6mo after surgery(P<0.05). The improvement effect in the experimental group was better than that in the control group(P<0.05).

CONCLUSION: The intravitreal injection of conbercept before PPV has a positive effect on reducing the incidence of intraoperative complications and promoting postoperative visual recovery in patients with PDR.