AIM: To analyze the clinical effect of intravitreal injection of Conbercept combined with retinal laser photocoagulation in the treatment of patients with diabetic macular edema(DME).

METHODS: Totally 73 patients(80 eyes)with type 2 diabetes and DME were enrolled in our hospital from June 2015 to December 2016, according to different treatment methods, and they were randomly divided into control group and treatment group. The control group were treated with retinal laser photocoagulation, and the treatment group were treated with intravitreal injection combined with laser photocoagulation. We observed the best corrected visual acuity(BCVA), retinal thickness and complications during the operation before treatment and 3mo after treatment.

RESULTS: At 3mo after treatment, the improvement of BCVA, the decreased value of average retinal thickness and retinal thickness at inferior, superior, temple and nasal in the treatment group were better than those in the control group and those after treatment was better than before(P<0.05). There was no statistically significant difference in the incidence of complications occurrence between the two groups(P>0.05). None of the patients had severe ocular complications such as corneal edema, anterior chamber inflammatory reaction, retinal hemorrhage, neonatal vascular glaucoma, endophthalmitis, etc. during follow up period.

CONCLUSION: Compared with applying laser photocoagulation alone, intravitreal injection of conbercept combined for DME is more effective with improved visual acuity, restored retinal function, and has good safety.