AIM: To explore the effect of levodopa and visual stimulation training in the treatment of adolescent ametropic amblyopia.

METHODS: Sixty-four adolescents(68 eyes)with ametropic amblyopia who treated in our hospital from May 2013 to May 2016 were included into this study, and the patients were randomly divided into the observation group(n=32, 33 eyes)and the control group(n=32, 35 eyes). The patients in the control group received visual stimulation training therapy, and the patients in the observation group were given levodopa on the basis of the control group. After treated for 24wk, the clinical effects and changes of P-VEP and visual sensitivity before and after treatment were compared.

RESULTS: After treated for 24wk, the total effective rate of the observation group(91%)was significantly higher than that of the control group(71%), and the difference was statistically significant(P<0.05). Although the amplitude of P-VEP P100 in the control group increased and the latency was shortened, the effect of the observation group was more significant, and the difference was significant(P<0.05).

CONCLUSIONS: Levodopa combined with visual stimulation training has significant effect in the treatment of adolescent ametropic amblyopia, it can better correct the visual sensitivity, and improve optic nerve conduction function.