AIM:To evaluate the efficacy of anti- vascular endothelial growth factor(VEGF)and photodynamic therapy(PDT)on pathological myopia(PM)combined with choroidal neovascularization(CNV)using ETDRS chart and multifocal electroretinogram(mfERG).

METHODS: Forty-three patients(45 eyes)diagnosed by fundus fluorescein angiography(FFA), indocyanine green angiograph(ICGA)and optical coherence tomography(OCT)with PM combined with macular CNV were recruited in this study. The patients were randomly divided into two groups for different treatments, intravitreal injection with Ranibizumab(20 patients, 22 eyes)and PDT(23 patients, 23 eyes). After treatment, all patients had been followed up monthly for 12mo. The further treatments were operated according to referral situations. The best corrected visual acuity(BCVA)was recorded with the ETDRS chart and mfERG. At the last follow-up, the therapy efficacy was determined by ETDRS numbers and mfERG and analyzed.

RESULTS:Before treatment, there was no significant difference on the baseline in ETDRS and mfERG latency of N1 wave, latency and the density values of P1 wave between ranibizumab group and PDT group. After 12mo treatment, the ETDRS number in ranibizumab group(39.23±20.06)significantly increased to the baseline by 5.88±9.03(P<0.05), and in PDT group(37.38±16.95)was not significantly improved by 0.33±6.94(P>0.05). There was no significant difference in latency of N1 wave, latency and the density values of P1 wave from treatment response of mfERG in the two groups(P>0.05).

CONCLUSION: In the treatment of macular CNV complicated by the PM, ranibizumab injection can improve visual function better than PDT, while similar on macular.