AIM: To evaluate the effect by optical coherence tomography angiography(OCTA)after intravitreal injection of Conbercept for wet age-related macular degeneration(wAMD)patients.

METHODS: The retrospective review included 18 patients(20 eyes)which were diagnosed with wAMD in Wuhu Ophthalmic Hospital from December 2016 to November 2017. All affected eyes were injected by conbercept, examined for the best corrected visual acuity(BCVA)and OCTA examine the foveal macular thickness(FMT), parafoveal macular thickness(PMT), choroidal neovascularization(CNV)flow area, foveal superficial vascular plexus flow density and parafoveal superficial vascular plexus flow density. The paired t test was used to compare those before and after treatment.

RESULTS: One months after treatment, the mean BCVA were improved with significant difference(P<0. 05). And the mean FMT, PMT, CNV flow area and foveal superficial vascular plexus flow density significantly decreased with significant difference(P<0.05), and the mean parafoveal superficial vascular plexus flow density decreased but with no statistical significance(P>0.05).

CONCLUSION: This study confirmed that the intravitreal injection of conbercept for treating wAMD is safe and effective. Intravitreal conbercept injections are associated with a significant change in native retinal and choroidal vasculature. OCTA could evaluate the effection of intravitreal injection of conbercept for wAMD more safely, objectively and conveniencely.