AIM:To observe the therapeutic effect of the mild form disseminated photocoagulation treatment for moderate non-proliferative diabetic retinopathy(MNPDR).

METHODS: Prospective randomized controlled study. Totally 126 cases(209 eyes)with MNPDR were randomly assigned to two groups in ophthalmology department of Shanghai Shidong Hospital. There were 62 cases(103 eyes)were treated with the mild form disseminated photocoagulation as the therapy group, 64 cases(106 eyes)were treated with control of blood glucose as the control group. All cases were followed up for 24mo. The best corrected visual acuity(BCVA), fundus change and central visual field were observed and compared.

RESULTS: At 24mo after treatment, BCVA variety between two groups took on significant statistical difference which indicated that there were more eyes with improved or stable visual acuity in therapy group(H_c=5.942, P<0.05). There was significant difference in fundus examination between two groups which indicated that there were more eyes with improved or stable fundus change in therapy group(H_c=12.662, P<0.05). There was no significant difference in average mean sensitivity(MS)between before and after laser therapy for 12mo(t=3.1586, P>0.05). During our follow-up, there were no complications likewise infection, hemorrhage, retinal membrane, injury of the macular fovear occurred.

CONCLUSION: The mild form disseminated photocoagulation therapy for moderate non-proliferative diabetic retinopathy is safe and effective without obvious complications, which can effectively delay the progression of diabetic retinopathy.