目的：对比分析青光眼患者联合可调整缝线的小梁切除术中使用丝裂霉素C(mitomycin C，MMC)与5-氟尿嘧啶(5-fluorouracil，5-FU)的临床预后及并发症。

方法：回顾性病例系列研究。选取本院2016-06/2017-10的71例71眼青光眼(包括原发性开角型青光眼和原发性慢性闭角型青光眼)患者，分为两组，其中MMC组36例，5-FU组35例，均给予联合可调整缝线的小梁切除术，分别使用MMC、5-FU抗瘢痕治疗，术后随访6mo，比较两组患者的临床眼压控制疗效、滤过泡形态及并发症发生率。

结果：MMC组患者术后眼压控制低于5-FU组，差异有统计学意义(P<0.05)，MMC组总手术成功率与5-FU组比较，差异无统计学意义(P>0.05)，MMC组功能性滤过泡形成率高于5-FU组，MMC组非功能性滤过泡形成率低于5-FU组，差异有统计学意义(P<0.05)，MMC组与5-FU组并发症发生率差异无统计学意义(P>0.05)。

结论：MMC及5-FU作为抗瘢痕药均能提高青光眼小梁切除手术的成功率，MMC能将眼压降到更低，形成功能性滤过泡方面MMC优于5-FU，根据患者制定个性化的手术方案MMC与5-FU的并发症发生率无明显差异，使用5-FU时需术后多次分离滤过泡及结膜下再次注射5-FU。

METHODS: Retrospective case series reseach was undertaken. We divided the 71 cases(including primary open angle glaucoma and primary chronic angle-closure glaucoma)into two groups: MMC group(36 cases)and 5-FU group(35 cases). Both were treated with combined adjustable sutural trabeculectomy with the usage of MMC or 5-FU anti-cicatricial treatment, and followed up to compare intraocular pressure, filtered bubble form and complications.

RESULTS: The intraocular pressure of MMC group was lower than 5-FU group with statistical significance(P<0.05); there was no significant difference in total surgical success rate between groups(P>0.05). Functional filtering bleb formation rate in MMC group was higher than 5-FU group while the formation rate of nonfunctional filtering bleb in MMC group was lower than 5-FU group(P<0.05), which showed no significant difference in complication rate between groups(P>0.05), but the types of complications were different.

CONCLUSION: Both MMC and 5-FU can improve the success rate of glaucoma trabeculectomy as anti-cicatricial drugs. MMC can lower the intraocular pressure, is superior to 5-FU in the formation of functional filtering bleb. There was no significant difference in the incidence of complications between MMC and 5-FU according to personalized surgical protocols based on patients. When 5-FU is used, it is necessary to separate the filtering blebs repeatedly after operation and to reinject 5-FU under conjunctiva.