The CRISPR/Cas system was a defense system originally found in bacterial immune system against exogenous genetic material(such as phage virus). With the precision in its targeting function, CRISPR/Cas system has been developed into a highly efficient genome-editing tool that has been widely used in various fields of life science research and has achieved revolutionary progress. This paper reviews the relevant literature on the application of the CRISPR/Cas system in human eye diseases.