AIM: To evaluate the interocular aberration root mean squares(RMS)characteristics among different severities of hyperopic anisometropic amblyopia.

METHODS: Sixty hyperopic anisometropic amblyopia were enrolled and divided into mild, moderate and severe groups. Each group was then divided into amblyopic eye(AE)and fellow eye(FE)subgroups according to the corrected visual acuity of each subject. All patients underwent wavefront analysis with iDesign^© wavefront aberration system(AMO, USA)in mydriasis condition. Paired t-test was used to compare interocular differences of aberration parameters within groups.

RESULTS: Paired t-test showed that significant differences in defocus equivalent(DE), BCVA between AE and FE in mild, moderate and severe anisometropic amblyopia(all P<0.01). No significant interocular difference was noticed in mild group except for forth-order aberration RMS(P<0.01). And No significant interocular differences were noticed in moderate and severe group except for total aberration RMS(both P<0.01). One-way ANOVA showed that significant interocular differences were noticed in third-order aberration RMS among the groups(P<0.01). LSD showed that interocular difference of third-order aberration RMS in moderate group was significant lower than that in mild and moderate groups(both P<0.05).

CONCLUSION: In mydriasis condition, mild anisometropic amblyopia showed higher forth-order aberration RMS in AE than that in FE, moderate and sever amblyopia showed higher total aberration RMS in AE than that in FE. Moderate anisometropic amblyopia manifested lower interocular differences of third-order aberrations RMS than mild and severe amblyopia, but no significant interocular differences observed between mild and severe amblyopia.