AIM: To explore the effect of lacrimal duct probing combined with tobramycin and dexamethasone ophthalmic ointment on ocular surface symptoms and quality of life of patients with lacrimal duct obstruction.

METHODS: A total of 120 patients(120 eyes)with lacrimal duct obstruction treated in the hospital from October 2016 to January 2018 were selected. They were randomly divided into control group(n=60)and observation group(n=60)according to the treatment methods. The control group was treated with simple lacrimal duct probing while the observation group was treated with lacrimal duct probing combined with illing with tobramycin and dexamethasone. The clinical efficacy, changes in ocular surface disease index(OSDI)score, levels of serum high-sensitivity C-reactive protein(hs-CRP)and procalcitonin(PCT)before and after treatment were compared between the two groups.

RESULTS: The clinical efficacy in observation group was significantly better than that in control group(P<0.05). The total score of OSDI, scores of the frequency of eye discomfort, the effect of eye discomfort on daily life and the frequency of eye discomfort caused by adverse environment in the observation group were significantly decreased after treatment(P<0.05). The levels of serum hs-CRP and PCT in the observation group were significantly lower than those in the control group after treatment(P<0.05).

CONCLUSION: Lacrimal duct probing combined with tobramycin and dexamethasone is markedly effective in the treatment of lacrimal duct obstruction. It can effectively relieve the ocular surface symptoms and improve quality of life of patients.