AIM: To compare the efficacy of invisible occlusion mirror and depressant membrane therapy in treatment of elderly amblyopia.

METHODS: Prospective study. Totally 112 cases(112 eyes)of monocular amblyopia aged 10-14 years were selected from June 2015 to December 2016 in our hospital. Among them, 55 cases(Group A)were treated with depressant membrane therapy and 57 cases(Group B)were treated with invisible concealer. The treatment compliance and efficacy of the two groups were evaluated, and the changes of corrected visual acuity before and after treatment were observed.

RESULTS: For 3, 6 and 12mo, there was no significant difference in treatment compliance between group A(98.2%, 96.4%, 92.7%)and group B(94.7%, 91.2%, 89.5%)(all P>0.05), but the effective rate of treatment(27.8%, 50.9%, 76.5%)was significantly lower than that of group B(46.3%, 71.2%, 92.2%), and the amblyopic corrected visual acuity of group B was better than that of group A(P<0.05). After 12mo treatment, the total and actual cure rates of group A(52.7% and 56.9%)were significantly lower than those of group B(71.9% and 80.4%).

CONCLUSION: The treatment of monocular amblyopia over 10 years old with invisible occlusion mirror is superior to that of depressor membrane occlusion in improving visual acuity and curing rate.