Corneal neovascularization(CNV)is a common cause of corneal diseases, but there is still no effective drug or treatment. At present, the common methods cannot inhibit the growth of CNV completely, cannot last for a long the therapeutic effect time, and there are also serious side effects, so the specific treatment of CNV inhibition is still being explored. The pathogenesis and treatment of CNV are the current research hotspots. CNV area is an important indicator to evaluate the efficacy of drugs and treatment regimens. There are multiple methods to develop CNV, including ink perfusion, immunofluorescence staining and so on, in recent years, optical coherence tomography(OCT)technology is also a potential new method. This article reviews the developing methods of CNV, hopes to provide a reference for the study of CNV.