AIM: To analyze curative effect of intravitreal injection of conbercept on branch retinal vein occlusion(BRVO)with macular edema(ME)and influencing factors of best corrected visual acuity(BCVA)after treatment.

METHODS: The clinical efficacy of 194 patients 194 eyes with BRVO-ME who underwent intravitreal injection of conbercept in the hospital from January 2016 to January 2018 were evaluated. The influencing factors of BCVA after treatment were analyzed by multivariate Logistic regression analysis.

RESULTS: The minimum resolution angular logarithm(LogMAR)vision of BCVA and retinal thickness(CMT)of macular fovea of the patients were significantly decreased compared with those before treatment. Although CMT showed a recovery trend at some time nodes, BCVA and CMT at any time point were significantly lower than those before treatment(P<0.05). Multiariable Logistic regression analysis showed that BRVO-ME-ischemic type, type of the ME-hybrid, ELM integrity-missing, missing IS/OS are affected patients with BRVO-ME the vitreous cavity of independent risk factors for compaq heap of injection effect, and the longer the course of the disease and the axial length, BCVA before treatment is higher, the vitreous cavity of treated by injection of compaq heap for the higher risk.

CONCLUSION: The curative effect of intravitreal injection of Conbercept is significant on BRVO-ME and safety is good. The poor BCVA recovery in some patients is effected by disease course, BRVO-ME types and other factors. The above factors should be fully evaluated before treatment and active response should be performed, for further optimizing the curative effect.