AIM: To evaluate the efficacy of nerve growth factor(NGF)in the treatment of glaucoma by Meta-analysis.

METHODS: Comprehensive computer search database according to Cochrane systematic evaluation method. Randomized controlled trials of glaucoma after NGF treatment in the past 5a were included, the data extraction and Meta-analysis were performed by using Revman 5.3 statistical software.

RESULTS: A total of 6 cases randomized controlled trials were included, all of which were in Chinese, totally 513 cases. At the end of the treatment period, visual acuity was detected in 5 of the studies and 6 studies were performed with intraocular pressure, the difference among cases and normal were not statistically significant \〖MD=0.10,95%CI(-0.05,0.25),P=0.19; MD= -0.90, 95%CI (-1.92, 0.11), P=0.08\〗; 5 studies were performed on the visual field and 3 studies performed visual evoked potential(VEP), included P100 wave latency and P100 wave amplitude, the difference was statistically significant \〖MD= -2.49, 95%CI (-4.02, -0.96), P=0.001; MD= -12.13, 95%CI (-17.30, -6.97), P<0.001; MD=1.34, 95%CI (0.93, 1.74), P<0.001\〗.

CONCLUSION: NGF can improve the visual field of patients with glaucoma, and also can improve image visual evoked potential P100 wave latency and P100 wave amplitude. However, the effect of improving visual acuity and reducing intraocular pressure is not obvious. In a word, the NGF can ameliorate the optic neuropathy.