目的：评估普拉洛芬滴眼液联合玻璃酸钠滴眼液对中重度干眼治疗的短期临床疗效及对患者心理状况的影响。

方法：选取2018-01/12于我院眼科就诊并治疗的中重度干眼患者318例，采用随机数字表法将患者分为试验组(238例)和对照组(80例)，其中对照组采用玻璃酸钠滴眼液治疗，试验组采用普拉洛芬滴眼液联合玻璃酸钠滴眼液治疗。治疗前、治疗后7、14、28d问卷调查患者的自觉症状及体征评分，检查结膜充血程度、泪膜破裂时间、角膜荧光素染色及泪液分泌情况，评估患者焦虑和抑郁程度。

结果：在患者的自觉症状及体征评分、结膜充血程度、泪膜破裂时间、角膜荧光素染色及泪液分泌方面，试验组在治疗后7d即有显著改善，且随着治疗时间的延长，效果更加显著，对照组在治疗后14d或28d逐渐好转； 同一治疗时间点，试验组疗效均明显优于对照组(P<0.05)。治疗后随着病情的好转，患者的焦虑或抑郁症状得到改善，试验组治疗后7d即有明显好转，对照组治疗后14d或28d逐渐好转； 同一治疗时间点，相比对照组，试验组患者的焦虑或抑郁程度均显著减轻(P<0.05)。

结论：普拉洛芬滴眼液联合玻璃酸钠滴眼液治疗干眼症起效快且疗效显著，患者自觉症状及体征显著改善，结膜充血和角膜荧光素染色减轻，泪膜破裂时间延长，泪液分泌量增加，患者焦虑或抑郁程度显著好转。

METHODS: From January to December 2018, 318 patients with moderate to severe dry eye were selected and treated in ophthalmology department of our hospital. The patients were divided into experimental group(238 patients)and control group(80 patients)by random number table method, and the control group was treated with sodium hyaluronate eye drops, while the test group was treated with pranoprofen eye drops combined with sodium hyaluronate eye drops. The general data of the patients were statistically analyzed. Before treatment, 7d, 14d, 28d after treatment, the patients' scores of conscious symptoms and signs were investigated by questionnaire, the degree of conjunctival congestion, tear breakup time, corneal fluorescein staining and tear secretion were examined, and the degree of anxiety and depression were evaluated.

RESULTS: There was no significant difference in general data between the two groups(P>0.05). In terms of patients' scores of conscious symptoms and signs, degree of conjunctival congestion, tear breakup time, corneal fluorescein staining and tear secretion, the experimental group was significantly improved 7d after treatment, and the effect was more significant with the prolonged treatment, while the control group was gradually improved 14 or 28d after treatment. At the same treatment time point, the efficacy of the experimental group was significantly better than that of the control group, and the difference was statistically significant(P<0.05). With the improvement of the condition after treatment, the anxiety or depression symptoms of the patients were improved. The experimental group was significantly improved 7d after treatment, while the control group was gradually improved 14d or 28d after treatment. At the same treatment time point, compared with the control group,the anxiety and depression degree of the patients in the experimental group were significantly reduced(P<0.05).

CONCLUSION: Pranoprofen eye drops combined with sodium hyaluronate eye drops for treatment of dry eye syndrome had fast and significant effect, patients' self-consciousness symptoms and signs are significantly improved, conjunctival congestion and corneal fluorescein staining are reduced, tear breakup time is prolonged, tear secretion is increased, and anxiety or depression are significantly improved.