AIM: To investigate the effect of puerarin combined with lecithin complex iodine tablets on hemostasis in patients with fundus hemorrhage.

METHODS: Totally 66 patients with fundus hemorrhage who entered into our hospital from April 2016 to March 2017 were collected and randomly divided into 2 groups: group A and group B, 33 cases(50 eyes)in each group. Group A was treated with lecithin complex iodine tablets, and group B was treated with puerarin combined with lecithin complex iodine tablets. Plasma viscosity index, serum homocysteine(Hcy), total cholesterol(TC)and triglyceride(TG)were measured and compared within 2 groups. The therapeutic effects and adverse reactions were compared between 2 groups.

RESULTS: Before treatment, there were no significant differences in plasma viscosity, serum Hcy, TC and TG between 2 groups(P>0.05). After treatment, the high blood viscosity, low blood viscosity, low plasma viscosity, plasma viscosity, Hcy, TC and TG in 2 groups had decreased than before treatment(P<0.001). Compared with group A, the high blood viscosity, low blood viscosity, plasma viscosity, Hcy, TC and TG had decreased(P<0.05). The total effect of group B were better than group A(P<0.05). The adverse reaction like thyroid changes, gastrointestinal reactions, mental excitement and bloating happened in 2 groups. There was no significant difference in the adverse reaction rate between 2 groups(P>0.05).

CONCLUSION: The efficacy of puerarin combined with lecithin complex iodine tablets in the treatment of fundus hemorrhage is significant, which is related to improving plasma viscosity and decreasing serum Hcy, TC and TG.