[关键词]
[摘要]
年龄相关性黄斑变性(ARMD)好发于50 岁及以上中老年人，呈进行性发展，可导致单眼或双眼部分甚至完全性视力丧失。虽然目前其发病机制尚不明确，但已有数据表明氧化应激在ARMD的发病过程中起到了重要作用。近年来对ARMD抗氧化机制方面的研究逐渐成为研究热点，本文就氧化应激介导ARMD的发生机制以及ARMD抗氧化剂的应用作一简要综述。
[Key word]
[Abstract]
Aged-related macular degeneration(ARMD)is prone to occur in the people who aged 50a or older. The disease can lead to partial or even complete loss of sight in single or both eyes progressively. The pathogenesis of ARMD is still unclear, but the previous studies have shown that oxidative stress plays an important role. The mechanism of antioxidants on ARMD has gradually become a hotspot in recent years. In this paper, we briefly reviewed the mechanism of ARMD caused by oxidative stress and the application of antioxidants on ARMD.
[中图分类号]
[基金项目]
国家自然科学基金委员会资助项目(No.81660167); 云南省科技计划项目(No.2017FB114); 云南省创新团队计划(No.2017HC010); 云南省重要眼表疾病预防和诊治新技术研究(No.2018ZF009)
