目的：调查分析糖尿病患者发生糖尿病性视网膜病变(DR)的影响因素及探讨康柏西普的治疗效果。

方法：选取2018-01/ 2019-07在本院进行治疗的糖尿病患者157例为研究对象，对患者进行眼科检查，根据检查结果统计患者的DR的患病率，并根据检查结果将患者分为DR组和非DR组。对两组患者的基础资料、临床资料等进行组间对比分析，并采用单因素和多因素Logistic回归分析探讨影响糖尿病患者发生DR的危险因素。并对DR组患者给予康柏西普干预治疗，观察评估康柏西普对DR患者的治疗效果。

结果：经诊断调查显示157例糖尿病患者中有DR患者44例63眼，患病率为28.0%。经单因素分析显示，DR组患者与非DR组患者在性别、体质量指数(BMI)、吸烟史、饮酒史、教育程度、冠心病史、血脂病史比较无差异(P>0.05)，而两组患者在糖尿病病程、年龄、眼科疾病史、降糖药服用情况、高血压病史比较有差异(P<0.05)。经Logistic多因素分析显示，高龄、长糖尿病病程、有眼科疾病史、有高血压病史、降糖药服用不规律均为糖尿病患者诱发DR的独立危险因素。DR组患者经康柏西普治疗后，患者的黄斑中心凹旁视网膜厚度(PMT)、血管内皮生长因子(VEGF)、胰岛素样生长因子-1(IGF-1)指标水平均低于治疗前，最佳矫正视力(BCVA)优于治疗前(P<0.05)。

结论：我院近期糖尿病患者伴发DR有较高的发病率，其疾病的诱发主要受到糖尿病病程(≥10a)、年龄(≥60岁)、眼科疾病史、降糖药服用情况、高血压病史等因素的影响。对DR患者给予康柏西普治疗后可获得良好的治疗效果，促进患者视力快速恢复。

METHODS:Totally 157 patients with diabetes who were treated in our hospital from January 2018 to July 2019 were selected as the research objects to carry out ophthalmic examination. According to the results of the examinations, the prevalence of DR was counted and the patients were divided into DR group and non-DR group. The basic data and clinical data of the two groups were compared and analyzed. The risk factors of DR in diabetic patients were explored by univariate analysis and multivariate Logistic regression analysis. The patients in DR group were treated with conbercept, and the therapeutic effect of conbercept on DR patients was observed and evaluated.

RESULTS:According to the diagnosis survey, there are 44 DR patients in 157 diabetic patients, 63 eyes in total, the prevalence rate is 28.0%. Univariate analysis showed that there was no significant difference in gender, body mass index(BMI), smoking history, drinking history, education level, history of coronary heart disease and blood lipid history between DR group and non-DR group(P>0.05), while there was a significant difference between the two groups in the duration of diabetes, age, history of ophthalmic diseases, the use of hypoglycemic drugs, and the history of hypertension(P<0.05). Logistic multivariate analysis showed that age, long course of diabetes, history of ophthalmic diseases, history of hypertension, irregular use of hypoglycemic drugs were independent risk factors for DR in diabetic patients. The parafoveal macular thickness(PMT), vascular endothelial growth factor(VEGF), insulin-like growth factor-1(IGF-1)and best corrected visual acuity(BCVA-LogMAR)of DR patients were lower than those before treatment(P<0.05).

CONCLUSION: The incidence of DR in diabetes mellitus patients in our hospital is relatively high in recent years, and its disease induction is mainly affected by diabetes course(≥10 years), age(≥60 years old), history of ophthalmic diseases, taking of hypoglycemic drugs, history of hypertension and other risk factors. The treatment of DR patients with conbercept can achieve good therapeutic effect and promote the rapid recovery of vision.