In a variety of eye diseases, such as glaucoma, macular degeneration and other diseases, the occurrence of oxidative stress is very common, oxidative stress can cause cell damage and apoptosis. The Sirtuins family(histone class III deacetylases), as regulators of a variety of cells, is widely expressed in various organs of the human body. Homologous genes of sirtuins(SIRT1)are also widely expressed in the eyes, and their expression and activation can play an anti-oxidative stress role, prevent cell senescence and damage, and thus prevent the progression of disease. This paper discusses the mechanism and expression of Sirtuins family in glaucoma, senile macular degeneration, optic neuritis and senile cataract.