AIM: To study the changes of serum IL-6, ADPN, Apelin, hs-CRP and VEGF levels in patients with RVO, and to explore their association with the occurrence and development of RVO from a molecular perspective.

METHODS:Totally 72 cases of RVO, including 35 cases of central retinal vein occlusion(CRVO)and 37 cases of branch retinal vein occlusion(BRVO). They were divided into groups 1 and 2. 32 senile cataract patients were collected as control group. The time of onset, visual acuity, history of cardio cerebral vascular disease and Macular edema thickness were recorded. Enzyme linked immunosorbent assay was used to detect the expression of IL-6, ADPN, Apelin, hs-CRP and VEGF in blood serum, which were closely related to inflammation and arteriosclerosis.

RESULTS: The mean value of Apelin in group BRVO was 6.69(4.25, 10.52)ng/mL, and CRVO group was 7.12(3.78, 8.58)ng/mL, and the two groups were higher than those in control group 1.19(0.74, 1.49)ng/mL(P<0.05). The mean value of ADPN in group BRVO was 8.06(4.67, 10.81)μg/mL, while in group CRVO was 9.74(4.10, 11.67)μg/mL. The mean value of IL-6 in group BRVO was 35.89(17.63, 37.50)pg/mL, while in group CRVO was 37.16(11.52, 42.80))pg/mL. The mean value of hs-CRP in group BRVO was 161.10(54.51, 164.01)μg/mL. The mean value of VEGF in group BRVO was 158.25(82.24, 230.41)pg/mL, while in group CRVO was 174.14(76.04,243.98)pg/ml(P>0.05). There was no significant difference between the experimental group and the control group.

CONCLUSION:By comparing the levels of serum IL-6, ADPN, Apelin, hs-CRP and VEGF in 72 RVO patients and 32 senile cataract patients, Apelin was found to be higher than that in the control group. Apelin may be one of the related risk factors for RVO. The expression of ADPN, IL-6, hs-CRP, VEGF, RVO in acute stage no specificity.