Long non-coding RNAs(LncRNAs)refer to RNAs that are longer than 200 nucleotides and cannot encode a protein. With the application of next-generation sequencing technology, whole-genome analysis shows that LncRNAs can regulate gene expression in immune response, epigenetic, gene transcription and post-transcriptional levels, thereby participating in the maintenance of cell proliferation and apoptosis, tissue homeostasis and other physiological processes. LncRNAs have been shown to involve in initiation and development of a variety of human diseases in recent years. This article reviews the research progress of LncRNAs in common diseases of ophthalmology, in order to early diagnosis and treatment of related ophthalmic diseases.