AIM: To investigate the effect on vision and complications of Conbercept combined with EX-PRESS glaucoma drainage device implantation for patients with neovascular glaucoma(NVG).

METHODS: Totally 128 cases of patients with NVG admitted to ophthalmology in our hospital from February 2016 to October 2018 were selected and divided into EX-PRESS group(n=66)and Trabeculectomy group(n=62)according to their treatment methods. Patients in both groups received conbercept intravitreal injection, patients in EX-PRESS group were treated with EX-PRESS glaucoma drainage device implantation, and patients in Trabeculectomy group were treated with Trabeculectomy. The surgical efficacy, postoperative intraocular pressure, visual acuity improvement and complications were compared between the two groups.

RESULTS: At 12mo postoperatively, the total successful rate of surgery in the EX-PRESS group and Trabeculectomy group were 81.8%(54/66)and 72.6%(45/62), respectively. There was no significant difference on the surgical efficacy between the two groups(P>0.05). At 1d, 7d, 1mo, 3mo, 6mo, 12mo postoperatively, the two group were significantly lower than preoperation(P<0.05), but there was no significant difference on intraocular pressure between the two groups(P>0.05). At 6mo, 12mo postoperatively, the vision improvement of EX-PRESS group was significantly better than that of Trabeculectomy group(P<0.05). The total postoperative complication rate of EX-PRESS group and Trabeculectomy group were 27.3%(18/66)and 37.1%(23/62), respectively(P>0.05).

CONCLUSION: The effectiveness and safety of conbercept intravitreal injection combined with EX-PRESS glaucoma drainage device implantation is similar to combined trabeculectomy for patients with NVG, and the former is more advantageous in improving eyesight.