AIM: To explore the influence of various related factors on ocular surface dysfunction in patients with type 2 diabetes mellitus.

METHODS: A total of 60 patients(60 eyes)with type 2 diabetes diagnosed in our hospital were chosen as diabetes group, 60 patients(60 eyes)without diabetes were chosen as control group. The subjects were tested including ocular surface disease index(OSDI), tear secretion(SⅠt)and the tear film break-up time(TBUT), tear meniscus height(TMH), corneal fluorescein staining(CFS).

RESULTS: All 65.94% of participants emerged dry eye(77.45% diabetics and 54.43% controls). In the diabetic group,OSDI and CFS were significantly higher(P<0.01), and BUT,SⅠt and TMH were significantly lower(P<0.05). Related analysis showed that duration of diabetes, glycemia and Hb1Ac were the influencing factors of symptoms in diabetic patients(P<0.05).

CONCLUSION: Diabetes patients are inclined to dysfunction in tear secretion and tear film, the longer of diabetes,and the higher of the glycemia and Hb1Ac, the worse the tear film stability were.