血-视网膜屏障损伤的机制及治疗对策

doi:10.3980/j.issn.1672-5123.2020.11.13

首页 > 过刊浏览>2020年第20卷第11期 >2020,20(11):1902-1906. DOI:10.3980/j.issn.1672-5123.2020.11.13

血-视网膜屏障损伤的机制及治疗对策

李敏
李敏
中国海南省海口市，海南医学院基础医学和生命科学学院
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莫诗雯
莫诗雯
中国海南省海口市，海南医学院基础医学和生命科学学院
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李伊
李伊
中国海南省海口市，海南医学院第一临床学院
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张全鹏
张全鹏
基础医学和生命科学学院; 海南省热带脑科学研究与转化重点实验室
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The mechanism and treatment of blood-retinal barrier injury

Min Li
Min Li
College of Basic Medicine and Life Sciences, Hainan Medical University, Haikou 571199, Hainan Province, China
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Shi-Wen Mo
Shi-Wen Mo
College of Basic Medicine and Life Sciences, Hainan Medical University, Haikou 571199, Hainan Province, China
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Yi Li
Yi Li
First Clinical College, Hainan Medical University,Haikou 571199, Hainan Province, China
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Quan-Peng Zhang
Quan-Peng Zhang
College of Basic Medicine and Life Sciences, Hainan Medical University, Haikou 571199, Hainan Province, China; Hainan Provincial Key Laboratory of Tropical Brain Research and Transformation, Hainan Medical University, Haikou 571199, Hainan Province, China
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发布日期：2020-10-22

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[关键词]

血-视网膜屏障 ; 糖尿病视网膜病变 ; 急性青光眼 ; 早产儿视网膜病变 ; 紧密连接蛋白 ; 血管内皮生长因子

[摘要]

血-视网膜屏障在维持视网膜微环境稳态中具有重要作用，很多疾病如糖尿病视网膜病变、急性青光眼、早产儿视网膜病变等均会导致血-视网膜屏障损伤。目前对于引起血-视网膜屏障损伤的分子机制尚未完全阐释清楚，本文旨在综述血-视网膜屏障的结构与功能，各种眼部疾病导致的血-视网膜屏障损伤机制及采用药物治疗、激光治疗、手术治疗的治疗对策。

[Key word]

blood-retinal barrier ; diabetic retinopathy ; acute glaucoma ; retinopathy of prematurity ; tight junction protein ; vascular endothelial growth factor

[Abstract]

The blood-retinal barrier(BRB)plays an important role in maintaining the homeostasis of the retinal microenvironment. Many diseases can lead to the damage of BRB, such as diabetic retinopathy, acute glaucoma and retinopathy of prematurity. At present, the molecular mechanism of BRB injury has not been fully explained. This paper briefly reviews the structure and function of blood-retina barrier, the damage mechanism of blood-retina barrier caused by various ocular diseases, and the therapeutic countermeasures of drug therapy, laser therapy and surgical treatment.

[中图分类号]

[基金项目]

国家自然科学基金项目(No.81660217); 国家级大学生创新创业培训计划项目(No.201911810004)

引用本文 / Get Citation

李敏,莫诗雯,李伊,等.血-视网膜屏障损伤的机制及治疗对策.国际眼科杂志, 2020,20(11):1902-1906.

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收稿日期: 2019-12-06

最后修改日期: 2020-09-27

在线发布日期: 2020-10-22

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