目的：分析糖尿病性白内障患者血清和房水中维生素C、氧化应激产物、炎症因子及血管内皮生长因子(VEGF)水平变化。

方法：选取2018-01/2019-12我院收治的糖尿病性白内障患者40例40眼作为观察组，单纯白内障患者40例40眼作为对照组。分析两组患者血液和房水样本中维生素C、氧化应激产物(丙二醛)、炎症因子(IL-6和IL-8)及VEGF水平的差异。

结果：两组患者血清维生素C水平无差异(P>0.05)，但观察组房水维生素C水平明显低于对照组(20.6±13.6mg/L vs 27.2±9.9mg/L，P<0.05)； 两组患者血清丙二醛水平无差异(P>0.05)，但观察组房水丙二醛水平明显高于对照组(12.6±4.6nmol/mL vs 8.0±3.1nmol/mL，P<0.001)； 观察组血清和房水IL-6、IL-8水平均明显高于对照组(P<0.001)； 两组患者血清VEGF水平无差异(P>0.05)，但观察组房水VEGF水平明显高于对照组(45.6±20.6pg/mL vs 16.5±4.5pg/mL，P<0.001)。

结论：糖尿病性白内障患者与单纯白内障患者相比，虽然血清维生素C、氧化应激产物及VEGF水平相似，但其房水中维生素C、氧化应激产物及VEGF水平存在较大的差异，同时糖尿病性白内障患者血清和房水炎症因子水平相比单纯白内障患者更高。

METHODS: From January 2018 to December 2019, 40 patients with diabetic cataract(40 eyes)were selected as the observation group, and 40 patients with simple cataract(40 eyes)were selected as the control group. The differences in the levels of vitamin C, oxidative stress products(malondialdehyde), inflammatory factors(IL-6 and IL-8)and VEGF in blood and aqueous humor samples of the two groups of patients were analyzed.

RESULTS: There was no difference in serum vitamin C levels between the two groups(P>0.05), but the aqueous vitamin C levels in the observation group were significantly lower than those in the control group(20.6±13.6mg/L vs 27.2±9.9mg/L, P<0.05); There was no difference in the serum malondialdehyde level of patients(P>0.05), but the aqueous malondialdehyde level of the observation group was significantly higher than that of the control group(12.6±4.6nmol/mL vs 8.0±3.1nmol/mL, P<0.001); Serum and aqueous humor IL-6 and IL-8 levels were significantly higher than those of the control group(P<0.001); there was no difference in serum VEGF levels between the two groups(P>0.05), but the observation group's aqueous humor VEGF levels were significantly higher than the control group(45.6±20.6pg/mL vs 16.5±4.5pg/mL, P<0.001).

CONCLUSION: Compared with patients with simple cataract, patients with diabetic cataract have similar serum vitamin C, oxidative stress products and VEGF levels, but there are greater differences in the levels of vitamin C, oxidative stress products and VEGF in their aqueous humor. At the same time, patients with diabetic cataracts serum and aqueous humor inflammatory factor levels are higher than those of patients with simple cataract.