Age-related macular degeneration(ARMD)is a major cause of irreversible visual impairment in the elderly in developed countries. Recent studies have shown that mitochondrial ferritin(FTMT)is thought to have an antioxidant effect through iron regulation. Therefore, this paper discusses the effects of FTMT on HIF-1α, FTMT gene mutation, and FTMT protection against oxidative stress on the progression of ARMD, so as to better understand the pathogenesis of the disease and contribute to the prevention or evaluation of the disease.