目的：研究急性前葡萄膜炎患者血清IL-35、TGF-β₁表达水平变化及两者之间的相关性，探讨IL-35、TGF-β₁在急性前葡萄膜炎中的临床意义。

方法：纳入2018-05/2019-05在甘肃省人民医院眼科确诊的急性前葡萄膜炎患者30例作为急性前葡萄膜炎组，同期进行体检的健康人30例作为健康对照组，采用ELISA法检测两组受检者血清IL-35、TGF-β₁表达水平，并根据改良的EIU临床评分标准评估急性前葡萄膜炎严重程度。

结果：急性前葡萄膜炎患者血清IL-35、TGF-β₁表达水平显著高于健康对照组(均P<0.05)，且急性前葡萄膜炎患者血清IL-35、TGF-β₁水平与疾病严重程度无明显相关性(r_s=0.087、0.044，均P>0.05)，但血清IL-35与TGF-β₁表达水平呈正相关(r_s=0.637，P<0.001)。

结论：血清IL-35、TGF-β₁水平变化与急性前葡萄膜炎的发生和发展密切相关，可能在急性前葡萄膜炎中协同发挥免疫抑制作用。

METHODS: Thirty patients with acute anterior uveitis confirmed in the Department of Ophthalmology of Gansu Provincial Hospital into 2018-05/2019-05 were selected as the case group, and thirty healthy patients who received physical examination at the Gansu Provincial Hospital during the same period were selected as the control group. Serum IL-35 and TGF-β₁ expression levels between the two groups were detected by Elisa. Modified endotoxin-induced uveitis(EIU)clinical standard was used for the severity of acute anterior uveitis.

RESULTS: Serum IL-35 and TGF-β₁ expression levels in the acute anterior uveitis group were significantly higher than that in the healthy control group(all P<0.05), and there was no significant correlation between serum IL-35 and TGF-β₁ levels as well as the severity of acute anterior uveitis(r_s=0.087, 0.044, all P>0.05). There was a significant positive correlation between serum IL-35 and TGF-β₁ expression levels in patients with acute anterior uveitis(r_s=0.637, P<0.001).

CONCLUSION: The expression levels of IL-35 and TGF-β₁ in serum are closely related to the occurrence and development of acute anterior uveitis and may play a synergistic role in immunosuppression in acute anterior uveitis.