AIM: To investigate the characteristics of fundus fluorescein angiography in patients with pigment incontinence and the significance of its adjuvant therapy.

METHODS: A retrospective study, we collected the clinical data of 10 patients(18 eyes)diagnosed retinopathy of pigment incontinence from March 2019 to August 2019. The patients were all female children, and they were 2 weeks-42 months old. The children's medical and family histories were recorded in detail, and fundus color photography and fundus fluorescein angiography were performed.

RESULTS: The results of fundus examination of 18 eyes of 10 children showed that 1 eye with stage 1, FFA showed that the retina was scattered with abnormal blood vessels, and there was no leakage in the late stage, and we will return to this regularly. 6 eyes with stage 2, FFA showed abnormal vascular anastomosis in the retina, and no obvious neovascularization, and all underwent laser photocoagulation. 9 eyes with stage 3, FFA showed fluorescence leakage of retinal neovascularization and fluorescence obscuration of preretinal hemorrhage, all of which underwent anti-VEGF vitreous injection combined with laser photocoagulation; 2 cases had monocular disease and the opposite eye was normal. 2 eyes with stage 4 and 1 eye with stage 4a, FFA showed that the optic disc and macula were pulled to the peripheral retina and partial retinal detachment, and vitrectomy was performed; 1 eye with stage 4b, the anterior segment was photographed, and a white mechanical film was behind the lens, B ultrasonography of the eye showed retinal detachment, and vitrectomy was performed.

CONCLUSION: This article preliminarily confirmed that fundus fluorescein angiography can assist in the staging and treatment of IP retinopathy, and had guiding significance for its follow-up treatment. However, there was no unified standard for the treatment of various stages of disease, and more clinical data were needed.