目的：通过网状Meta分析评价中医药不同干预措施治疗外伤性视神经病变的临床疗效。方法：计算机检索中文数据库(CNKI、VIP、WanFang、SinoMed)和英文数据库(PubMed、Embase、Cochrane Library)自建库至2020-03已发表的关于中医药治疗外伤性视神经病变的随机对照临床试验(RCT)文献，采用Cochrane评价工具对纳入研究进行质量评价，运用Stata 14.2软件进行网状Meta分析。结果：纳入21项RCT研究，患者1 297例，涉及7种干预措施，其中中药、中药+激素类药物、针灸+中药+营养神经类药物治疗后视力改善情况优于单纯使用营养神经类药物，中药+激素类药物、针灸+中药+营养神经类药物、针灸+中药+激素类药物治疗后视力改善情况优于单纯使用激素类药物(P<0.05)，治疗有效率排序第一位的干预措施是针灸+中药+营养神经类药物。结论：中医药治疗外伤性视神经病变具有优势，其中针灸+中药+营养神经类药物成为最优选择的可能性最大。

AIM:To evaluate the clinical efficacy of different interventions of traditional Chinese medicine in the treatment of traumatic optic neuropathy by means of mesh Meta-analysis.METHODS:The Computer searched of Chinese databases(CNKI, VIP, WanFang, SinoMed)and English databases(PubMed, Embase, Cochrane Library). Search time was limited from their inception to March 2020. Randomized controlled clinical trials of traditional Chinese medicine for treatment of traumatic optic neuropathy were subjected to Meta-analysis. Cochrane evaluation tool was used to evaluate the quality of the included studies and Stata 14.2 software was used to conduct network Meta-analysis.RESULTS: Twenty-one RCT studies involving 1 297 patients were included and 7 interventions were involved. Among them, Chinese medicine, Chinese medicine+hormone drugs, acupuncture+Chinese medicine+neurotrophic drugs were better than those with neurotrophic drugs alone. Chinese medicine+hormone drugs, acupuncture+Chinese medicine+neurotrophic drugs, acupuncture+Chinese medicine+hormone drugs were better than that of hormone drugs alone(P<0.05), and the intervention measures ranked first in terms of effective treatment rate is acupuncture+Chinese medicine+neurotrophic drugs.CONCLUSION: Chinese medicine has advantages in the treatment of traumatic optic neuropathy. Among them, acupuncture+ Chinese medicine+neurotrophic drugs is most likely to be the best choice.

中华中医药学会“外伤性视神经病变的中医诊疗指南”项目; 国家自然科学基金项目(No.81503453)