目的：分析全飞秒激光小切口角膜基质透镜取出术(SMILE)对角膜表面规则指数(SRI)的影响。方法：回顾性病例研究。选取2017-01/2019-12秦皇岛视光眼科医院210例401眼近视患者为研究对象，依据采取的矫正手术将其分为观察组110例205眼行SMILE，对照组100例196眼行飞秒激光辅助的准分子激光原位角膜磨镶术(FS-LASIK)。比较两组患者手术前后裸眼视力(UCVA)、最佳矫正视力(BCVA)、角膜前表面6mm范围的非球面参数Q值和SRI。结果：术后3、6mo两组患者UCVA、BCVA均较术前改善(P<0.05)，但组间比较无差异(P>0.05)； 观察组术后3、6mo、1a SRI高于对照组(P<0.05)； 术后两组患者各时点非球面参数Q值均高于术前，且观察组术后6mo，1a非球面参数Q值低于对照组(P<0.05)。结论：与FS-LASIK相比，SMILE术后有相似的视力恢复效果，但SMILE术后SRI大、对非球面参数Q值影响小。

AIM: To analyze the influence of total femtosecond laser small incision lenticule extraction(SMILE)on corneal surface regularity index(SRI).METHODS:Totally 210(401 eyes)myopic patients treated in Qinhuangdao Optometry Ophthalmology Hospital between January 2017 and December 2019 were enrolled in the study. Among them, patients treated with total femtosecond laser SMILE were included in the observation group(n=110, 205 eyes), while those treated with femtosecond laser-assisted in situ keratomileusis(FS-LASIK)were includded in the control group(n=100, 196 eyes). The uncorrected visual acuity(UCVA), best corrected visual acuity(BCVA), anterior corneal surface asphericity index(Q-value)at a diameter of 6mm and SRI were compared between the two groups before and after operation.RESULTS: The UCVA and BCVA of both groups were improved at 3mo and 6mo after operation(P<0.05), without significant differences between the groups(P>0.05). The observation group had higher SRI than the control group at 3mo, 6mo and 1a(P<0.05). The asphericity parameter Q-values increased at each time point after operation. Besides, the observation group had lower Q-values than the control group at 6mo and 1a(P<0.05).CONCLUSION: Compared with FS-LASIK, SMILE can achieve similar visual recovery effect. However, the SRI is larger after SMILE, and the influence on asphericity index Q-value is less.