Mesenchymal stem cells(MSCs)are pluripotent stem cells which are derived from avariety of tissues and have the potential for multidirectional cell differentiation and self-cell renewal. They can play a therapeutic effect on a variety of eye diseases. Studies have shown that the biological functions of MSCs are closely related to their secreted exosomes(MSC-Exo). Compared with MSCs, the biological performance of MSC-EXO is more stable and non-tumorigenic. Therefore, MSC-EXO is expected to be an effective substitute for the biological function of MSCs. In this paper, the application progress of MSC-EXO in ocular diseases is discussed in order to provide ideas and reference for the treatment of MSC-EXO in ocular diseases.