[关键词]
[摘要]
目的：采用Meta分析方法评价相干光断层扫描血管成像(OCTA)对湿性年龄相关性黄斑变性(wARMD)患者脉络膜新生血管(CNV)的诊断价值。
方法：计算机检索PubMed、Embase、Web of science、Cochrane library、CNKI、Wanfang、CBM和VIP数据库建库至2020-10-27关于OCTA诊断wARMD患者CNV的相关研究。由两位研究员独立筛选文献、提取资料并采用QUADAS-2工具评价纳入研究的偏倚风险，使用Meta-Disc 1.4及Stata 16.0软件进行Meta分析。
结果：纳入文献11篇，患者995眼。OCTA诊断wARMD患者CNV的Meta分析结果显示，合并灵敏度、特异度、阳性似然比、阴性似然比、诊断比值比、sROC曲线下面积和阳性验后概率依次为0.88\〖95%CI(0.83，0.92)\〗、0.95\〖95%CI(0.85，0.99)\〗、18.45\〖95%CI(5.36，63.52)\〗、0.12\〖95%CI(0.08，0.18)\〗、152.73\〖95%CI(36.39，641.05)\〗、0.95\〖95%CI(0.92，0.96)\〗和0.96。
结论：相干光断层扫描血管成像用于诊断wARMD患者CNV具有较高价值，尤其适用于wARMD的早期诊断。
[Key word]
[Abstract]
AIM: To evaluate the diagnostic value of optical coherence tomography angiography(OCTA)in detecting the choroidal neovascularization(CNV)of wet age-related macular degeneration(wARMD).
METHODS: PubMed, Embase, Web of science, Cochrane library, CNKI, Wanfang, CBM and VIP databases were searched from inception to October 27, 2020 in diagnosing CNV of wARMD by OCTA. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies by QUADAS-2 standard. Meta-analysis was performed by Meta-Disc 1.4 and Stata 16.0 softwares.
RESULTS: A total of 11 studies involving 995 eyes were included. The results of Meta-analysis showed that the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic ratio, the AUC of sROC and the positive post-test probability were 0.88 \〖95%CI (0.83, 0.92)\〗, 0.95 \〖95%CI (0.85, 0.99)\〗, 18.45 \〖95%CI (5.36, 63.52)\〗, 0.12 \〖95%CI (0.08, 0.18)\〗, 152.73 \〖95%CI (36.39, 641.05)\〗, 0.95 \〖95%CI (0.92, 0.96)\〗 and 0.96 respectively.
CONCLUSION: OCTA has significant diagnostic value for CNV of wARMD, especially for patients with early wARMD.
[中图分类号]
[基金项目]
中国博士后科学基金资助项目(No.2019M651927); 南通市科技计划项目(No.JCZ19081)
