Tongji Hospital, School of Medicine, Tongji University, Shanghai, China
The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)
Transient receptor potential vanilloid receptor 4 ( TRPV4 ) is a non-selective cation channel responsible for sensing changes in cell swelling, temperature, mechanical stretch, shear stress and osmotic pressure by regulating transmembrane calcium signaling and thereby influencing gene expression, cell morphology, and cytoskeletal construction. TRPV4 is widely expressed in various organs and tissues throughout the body. In the eyes, TRPV4 is functionally expressed in the cornea, lens, ciliary body, trabecular meshwork and retina. In this article, we described the expression and physiopathological functions of TRPV4 in various tissues of the eye. With the in-depth study of TRPV4 in ocular pathophysiological functions, TRPV4 may become a potential drug target in corneal injury repair, adjustment of the optical properties of the lens, controling intraocular pressure and retinal angiogenesis, but further in-depth study is still needed.