Nanjing University of Chinese Medicine
Neurotrophic keratitis (NK) is a degenerative corneal disease caused by impairment of trigeminal innervations. It can lead to corneal epithelial defects, corneal ulceration, and perforation. Early diagnosis of NK is crucial and requires accurate investigation of clinical history and thorough examination of ocular surface to determine clinical stage. Treatment for NK needs to be divided into stages according to disease severity. In addition to conventional treatments including artificial tears, blepharorrhaphy, and amniotic membrane transplantation, this article details emerging treatments such as targeted drug therapy and corneal neurotization, in order to provide some reference for the treatment of NK.This article summarized the epidemiology, clinical manifestations and classification, etiology, diagnosis, differential diagnosis and treatment of NK, in order to provide reference for the early diagnosis and treatment of NK in the future.