蛋白质组学技术在针刺治疗干眼中的作用和研究进展
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南京中医药大学

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国家自然科学基金项目(面上项目,重点项目,重大项目)


Effect of proteomics on treating dry eye disease with acupuncture and its mechanism
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nanjing university of Chinese medicine

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The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    干眼是指由泪液的质、量和动力学异常等原因导致的泪膜稳定性下降或眼表微环境失衡,造成多种眼部不适甚至视功能障碍。其发病机制复杂,目前治疗尚局限于缓解症状,保护视功能。针刺治疗干眼有效,但作用机理尚未完全明确。挖掘针刺干预的调控机制,将为针刺治疗的理论研究和针刺作用的基础研究提供依据。蛋白质组学技术能系统全面反应蛋白质的功能、结构以及相互作用关系,将蛋白质组学技术应用于针刺治疗干眼的研究,不仅可从不同病因病程揭示干眼蛋白质水平的动态变化,寻找潜在生物标志物,还能系统挖掘针刺治疗干眼的调控机制。本文旨在探讨蛋白质组学在干眼临床和基础研究中的潜在应用价值,为干眼的诊疗及针刺机制研究提供科学有效的思路。

    Abstract:

    Dry eye disease (DED) refers to a condition characterized by reduced stability of the tear film or an imbalance in the microenvironment of the ocular surface, resulting from abnormalities in tear quality, quantity and kinetics. This condition leads to various ocular discomforts and even visual impairment. The pathogenesis of DED is multifactorial and current treatment options mainly focus on symptom relief and preservation of visual function. Acupuncture has shown effectiveness in treating dry eye, although its underlying mechanism of action remains incompletely understood. Investigating the regulatory mechanisms involved in acupuncture intervention can provide a theoretical basis for acupuncture treatment research and contribute to the understanding of its effects at a fundamental level. Proteomics technology offers a comprehensive and systematic approach to studying the functions, structures and interactions of proteins. Its application in DED research can provide valuable insights into the dynamic changes in protein levels associated with different etiological processes of DED and facilitate the identification of potential biomarkers. Furthermore, proteomics can systematically explore the regulatory mechanisms underlying acupuncture treatment for DED. By integrating proteomics technology into DED research, we can uncover novel perspectives and enhance our understanding of this condition. This paper aims to explore the potential application of proteomics in both clinical and basic research on DED. Ultimately, it strives to offer scientific and effective strategies for the treatment of DED and advance our knowledge of the mechanisms underlying acupuncture therapy.

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  • 收稿日期:2023-04-04
  • 最后修改日期:2023-07-23
  • 录用日期:2023-07-12
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